HFpEF: Cardiovascular Abnormalities Not Just Comorbidities
نویسندگان
چکیده
منابع مشابه
HFpEF: cardiovascular abnormalities not just comorbidities.
T wenty-five years ago, the understanding of heart failure (HF) was straightforward. HF was a clinical syndrome due to left ventricular (LV) systolic dysfunction apparent as a reduced ejection fraction (EF). Based on this understanding , large randomized trials were conducted using an EF<0.30 or 0.35 as a key entry criterion. These studies demonstrated that the use of angiotensin-converting enz...
متن کاملHFpEF or just multiple comorbidities? The challenges of making a definitive diagnosis
Heart failure is a complex clinical syndrome resulting from the inability of the heart to meet the metabolic needs of the body at normal ventricular filling pressures. The clinical manifestations are breathlessness, fatigue, and fluid retention. It is a progressive disease, characterized by high rates of hospitalization that tend to increase over time. Studies have suggested that approximately ...
متن کاملMineralocorticoid receptors and cardiovascular damage: it's not just aldosterone.
Adecade before aldosterone was isolated and characterized, Hans Selye showed that administration of deoxycorticosterone acetate to rats sensitized by salt loading produced a vascular inflammatory response (polyarteritis) and tissue fibrosis. Fifty years later, Karl Weber and his colleagues showed that aldosterone and inappropriate salt intake produced cardiac hypertrophy and fibrosis1; this res...
متن کامل[Cardiovascular comorbidities and obstructive sleep apnea].
Mailing Address: Fátima Dumas Cintra • Av. Marcos Penteado de Ulhoa Rodrigues, 1001 06543-330 – Santana de Parnaíba, SP Brazil E-mail: [email protected] Received on 12/08/05 • Accepted on 12/28/05 Obstructive sleep apnea-hypopnea syndrome (OSAHS) is a prevalent condition in the general population. It is associated with increased cardiovascular risk and often goes unrecognized. Its di...
متن کاملObstructive Sleep Apnea and Cardiovascular Comorbidities
Obstructive sleep apnea (OSA) is a common disorder, characterized by cyclic cessation of airflow for 10 seconds or more. There is growing awareness that OSA is related to the development and progression of cardiovascular disease. However, only a few studies have associated OSA directly to major cardiovascular events. The aim of this study was to evaluate the relationship between OSA and cardiov...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Circulation: Heart Failure
سال: 2012
ISSN: 1941-3289,1941-3297
DOI: 10.1161/circheartfailure.112.972265